身体虚弱,遗传倾向,以及发生的心律失常
Yucong Zhang1,2, Man Liu1,2, Jiajun Li3
1Department of Geriatrics, Institute of Gerontology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of cachexia, sarcopenia and muscle
|June 9, 2024
概括
身体虚弱在纵向上与患心律失常,包括心房动 (AF) 的风险更高有关. 管理虚弱可能是预防心律失常和改善心血管健康的重要因素.
科学领域:
- 老年学是指老年学的学科.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 截面研究表明,虚弱和心房动 (AF) 之间存在联系.
- 脆弱性和发生性心律失常之间的纵向关联仍然不清楚.
- 这项研究研究了虚弱表型和发生性心律失常,特别是AF之间的纵向关系.
研究的目的:
- 为了确定身体脆弱的表型是否与发生的心律失常长度相关.
- 评估虚弱与新发动的心房动之间的关联.
- 为了确定特定的脆弱成分,预测心律失常的发展.
主要方法:
- 使用英国生物库数据进行前性队列研究.
- 排除具有基线心律失常,缺少脆弱数据或遗传数据的参与者.
- 对五个身体脆弱领域的评估:体重减轻,疲劳,身体活动低,握力低,步行速度缓慢.
- 使用142个SNP计算AF多基因风险评分 (PRS).
- 通过医院住院病人和死亡记录识别发生的节律失常.
主要成果:
- 包括464,154名中年和老年人没有基线心律失常.
- 随访时间中位数为13.4年,发现了46,454例新发性心律失常.
- 虚弱前期和虚弱前期与AF风险增加有关 (HR分别为1.12和1.44).
- 缓慢的步行速度是所有心律失常的最强有力的预测因素,包括AF.
- 遗传倾向 (PRS) 和对发生性AF风险的脆弱性之间的显著相互作用.
结论:
- 身体的脆弱性和脆弱性与发生的心律失常有显著且独立的联系.
- 研究结果表明,评估和管理虚弱性对于预防心律失常的重要性.
- 需要进一步的研究来验证直接因果推断的有效性.
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