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多化二乙烯和妊娠期体重增加:一个多中心前性队列研究

Zifan Wang¹, Paige L Williams^2,3, Andrea Bellavia¹

¹Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

BJOG : an international journal of obstetrics and gynaecology

|June 10, 2024

概括

聚二乙烯 (PBDE) 与没有肥胖症的女性的妊娠期体重增加无关. 然而,在肥胖女性中,PBDE 47与妊娠期体重增加有着一致的关联.

科学领域:

环境健康环境健康
生殖健康生殖健康
毒理学毒理学毒理学

背景情况:

聚二乙烯 (PBDE) 是阻燃剂,具有潜在的内分泌干扰性.
怀孕期间暴露于PBDE是令人担忧的,因为它可能对母亲和胎儿的健康产生影响.
孕期体重增加 (GWG) 是影响怀孕结果的关键因素.

研究的目的:

调查妊娠早期PBDE的血度与GWG之间的关联.
根据孕前母亲的肥胖状况来区分这些关联.

主要方法:

一项前性队列研究,涉及2052名没有肥胖的妇女和397名肥胖妇女.
测量第一季度的血PBDE度和整个怀孕期间的GWG.
应用通用线性模型和贝叶斯内核机器回归 (BKMR) 进行关联分析.

主要成果:

在没有肥胖的女性中,没有观察到PBDE和GWG测量之间的显著关联.
在肥胖女性中,PBDE 47的增加与较高的总GWG和GWG速度有关.
PBDE 47,99和100与肥胖女性实现低GWG轨迹的几率较低有关.

结论:

在非肥胖的孕妇中,PBDE与GWG无关.
在肥胖女性中,PBDE 47与GWG测量表现出一致的积极关联.
需要进一步的研究来证实这些发现,并阐明潜在的机制.

关键词:

怀孕期间体重增加.混合物混合物混合物混合物聚化二乙烯乙烯的多化二乙烯.怀孕怀孕怀孕怀孕怀孕

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