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在动物园管理的戈尔迪子 (Callimico goeldii) 中,口腔皮细胞癌

Andrew F Rich¹, Imogen L Payne², Rowena Killick¹

¹International Zoo Veterinary Group, Keighley, UK.

Journal of medical primatology

|June 10, 2024

概括

戈尔迪的口腔状细胞癌 (OCSCCs) 可能是侵入性的,但很少转移. 需要进一步的研究,因为疹病毒和COX-2与这些瘤无关.

科学领域:

兽医病理学兽医病理学
灵长类瘤学
比較瘤學的相關搜尋

背景情况:

口腔状细胞癌 (OCSCCs) 在非人类灵长类动物中很常见.
在戈尔迪的子中,OCSCC的记录很少.

研究的目的:

为了记录Goeldi的子中的OCSCC.
调查与疹病毒和COX-2表达的潜在关联.

主要方法:

在OCSCC的四只Goeldi的子身上进行了尸检,细胞学和组织病理学.
胰岛素,E-cadherin和COX-2的免疫组织化学.
泛疹病毒PCR分析.

主要成果:

四分之三的OCSCC是侵入性的,其中三例是骨入侵.
新生细胞表达胰岛素和E-cadherin.
没有发现区域性淋巴结或远程转移. 所有病例均为疹病毒和COX-2阴性.

结论:

戈尔迪子中的OCSCC可以是深度入侵的,但并不容易转移.
没有发现与疹病毒或COX-2表达的关联.
由于缺乏COX-2表达,NSAID化疗不太可能有效.

关键词:

在 Callimico goeldii 的位置上.子,子,子,子,子,子,子,子.这种新生病 neoplasia.非人类灵长类灵长类动物.状细胞癌的癌症.

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