一种非对称的NIR-II有机光体,具有超大冲动转移,用于成像引导和向光疗
Mengyao Li1,2, Weiping Zhou1,2, Wei Zhou1,2
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
ACS biomaterials science & engineering
|June 10, 2024
概括
研究人员开发了一种新的近红外II (NIR-II) 光探测器,该探测器被纳米粒子封装. 这种探针可实现精确的瘤成像和向光疗,证明了改善癌症治疗结果的巨大潜力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 医疗成像医学成像
背景情况:
- 近红外II (NIR-II) 光成像为增强瘤可视化提供深层组织透.
- 开发用于NIR-II成像的大型斯托克斯转移的小分子染料仍然是一个重大挑战.
- 针对性地提供光疗剂对于提高治疗疗效和尽量减少副作用至关重要.
研究的目的:
- 设计和合成一个新的不对称的D-π-A型NIR-II光探针 (TBy) 具有很大的斯托克斯转移.
- 通过封装TBy探头并将其修改为瘤向的CREKA质来构建向纳米粒子 (TByC-NP).
- 评估用于NIR-II成像指导光疗的TByC-NP,并评估它们的抗瘤疗效.
主要方法:
- 一种非对称的D-π-A型小分子染料 (TBy) 的合成,具有NIR-II光发射.
- 将TBy探针封装在两性聚合物中,并用CREKA进行修改,以形成TByC-NPs.
- 描述TByC-NP的光特性,包括发射波长和斯托克斯转移.
- 通过体外和体外研究评估TByC-NP的瘤向能力,生物相容性,光热和光动力学治疗效应.
主要成果:
- TByC-NPs在1037纳米处呈现NIR-II光辐射,具有创纪录的426纳米的Stokes转移.
- 这些纳米颗粒显示出有效的瘤向,这是由于CREKA基修饰.
- 在体外和体外模型中,TByC-NP显示出出色的生物相容性,强大的光热和光动力治疗能力,以及显著的抗瘤作用.
结论:
- 开发的TByC-NP代表了NIR-II成像指导光疗的有希望的纳米平台.
- 探测器的大斯托克斯转移和有针对性的传递增强了成像分辨率和治疗精度.
- 这种方法为有效的癌症治疗提供了可行的策略,提高了安全性和有效性.
相关概念视频
Total Internal Reflection Fluorescence Microscopy
Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
Super-resolution Fluorescence Microscopy
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.


