定向深度大脑刺激编程:该片段是否可以清晰识别并随着时间的推移而稳定?
Jessica A Karl1, Jessica M Joyce2, Bichun Ouyang2
1Movement Disorder Division, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Movement disorders clinical practice
|June 10, 2024
概括
针对帕金森病 (PD) 的最佳定向深度大脑刺激 (d-DBS) 编程设置显示程序员之间和随着时间的推移之间的一致性较低. 这表明重新评估刺激设置对于有效的PD管理很重要.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 在帕金森病 (PD) 中,定向深度大脑刺激 (d-DBS) 编程可能需要随着时间的推移进行调整.
- 调查最佳电极选择的一致性对于可靠的d-DBS治疗至关重要.
研究的目的:
- 为了评估PD的d-DBS编程中最佳电极选择的可靠性和稳定性.
- 为了评估在时间的推移中对最佳电极选择的inter-rater和intra-rater协议.
主要方法:
- 这是一项前性双盲研究,涉及21名接受d-DBS的PD患者.
- 单极调查是由两个独立的评估者在1个月和6个月后四次进行.
- 主要目标:评价者之间的协议;次要目标:评价者内部协议.
主要成果:
- 在1个月内达成公平的互评价协议,在6个月后改善到适度.
- 在1至6个月之间观察到最小的内定价协议.
- 该研究的高达成一致的假设被驳斥了.
结论:
- 低达成协议表明,确定最佳电极或急性刺激变化的主观性质.
- 程序员应该考虑定期探索不同的电极组装.
- 检查定向电极安装最好以临床症状或疾病进展为指导.
相关概念视频
01:35Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
01:25Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...