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基于角度的最小侵入性玻璃眼外科手术在正常张力玻璃眼:一个系统的审查和元分析

Hnin Hnin Oo¹, Ashley Shuen Ying Hong², Sheng Yang Lim¹

¹Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.

Clinical & experimental ophthalmology

|June 10, 2024

概括

基于角度的微创性玻璃眼外科手术 (MIGS) 有效降低眼内压力 (IOP) 并减少玻璃眼药物在正常张力玻璃眼 (NTG) 患者. 这种手术方法提供了持续的IOP控制,直至手术后36个月.

科学领域:

眼科医生眼科眼科
手术创新在外科创新.
玻璃眼研究研究玻璃眼研究

背景情况:

正常张力玻璃眼 (NTG) 在眼压管理方面提出了独特的挑战.
基于角度的微创性玻璃眼手术 (MIGS) 提供了一个不那么侵入性的手术选择.
在NTG中量化基于角度的MIGS在NTG中的有效性对于治疗指南至关重要.

研究的目的:

系统地审查和分析基于角度的MIGS在NTG患者的有效性.
评估眼内压力 (IOP) 的降低和抗光眼瘤药物 (AGM) 的使用.
评估这些程序的长期结果.

主要方法:

在主要医疗数据库 (Medline,Embase,PubMed,CINAHL,Cochrane Library) 进行了全面的文献搜索,直到2022年12月.
包括的研究包括试点,队列,观察和随机对照试验,涉及至少5名接受基于角度的MIGS的NTG患者.
进行了元分析,使用R来确定手术后平均IOP和AGM减少.

主要成果:

分析了15项研究,其中367只眼睛接受了联合发酵乳和基于角度的MIGS.
在手术后6,12,24和36个月观察到IOP和AGM的显著减少 (p <0.05).
对发泡乳化-iStent注射的亚组分析显示,12个月后IOP和AGM显著减少.

结论:

基于角度的MIGS与化相结合是一种有效的治疗方法,可以减少NTG中的IOP和AGM.
在NTG中基于角度的MIGS的好处持续长达36个月.
这一元分析支持使用基于角度的MIGS作为NTG管理的可行外科选择.

关键词:

最少侵入性的玻璃眼外科手术.正常张力格拉瘤格拉瘤

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