在维生素D补充的临床试验中影响产后骨矿物质密度的因素
Amy E Wahlquist1,2, Harry H Blanke3, Golaleh Asghari4
1Department of Biostatistics & Epidemiology, Center for Rural Health Research, East Tennessee State University (ETSU), Johnson City, Tennessee, USA.
Journal of women's health (2002)
|June 10, 2024
概括
母亲的骨矿物质密度 (BMD) 可以在哺乳期间降低,但更高的BMI,体力活动和维生素D补充剂可以防止骨质损失. 母乳养与骨质量损失有关,而配方养则显示了收益.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 营养科学 营养科学
背景情况:
- 关于维生素D在哺乳期对母亲骨矿物质密度 (BMD) 的影响的研究有限,特别是在多样化的群体中.
- 诸如种族/种族,体重指数 (BMI) 和体力活动等因素在产后骨健康方面往往没有得到充分研究.
研究的目的:
- 研究维生素D状态和维生素D补充剂对产后母亲骨硬化的影响.
- 分析养类型,BMI,种族/族裔和体育活动如何影响BMD变化至产后7个月.
主要方法:
- 随机对照试验,使用两个维生素D剂量组 (400 IU/天与6400 IU/天).
- 通过DXA测量BMD (部,脊椎,大腿部,全身),血清25-基维生素D [25(OH) D],BMI,以及分娩后1,4和7个月的身体活动.
- 使用一般线性混合建模进行统计分析,以评估影响BMD的因素.
主要成果:
- 哺乳期妇女经历了1-3%的BMD损失,而非哺乳期妇女显示了1-3%的收益.
- 较高的BMI与部和大腿部区域的骨损失较少相关.
- 与白人/白人或西班牙裔女性相比,美国黑人女性的骨质量损失较少.
- 更高的维生素D补充剂 (6400 IU) 减少了仅母乳养妇女的股骨部 BMD 损失.
- 身体活动与部 BMD 的增加有关.
结论:
- 哺乳期与骨质量损失有关,尽管可能比以前报告的速度更低,具有显著的种族/民族差异.
- 较高的BMI和体力活动似乎对部BMD有保护作用.
- 增加维生素D补充剂可以在哺乳期间提供保护,防止股骨部 BMD 损失.
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