在使用固酶5抑制剂的个体中,眼睛后部结构的变化
Mehmet Icoz1, Fatih Kocamanoglu2
1Department of Ophthalmology, Yozgat City Hospital, Yozgat, Turkey.
Current eye research
|June 10, 2024
概括
每日使用塔达拉菲尔治疗勃起功能障碍并没有显著改变后眼部结构. 光学连贯性断层扫描显示,在治疗一个月后,视网膜厚度或光盘测量没有变化.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 固酶5抑制剂 (PDIs) 通常用于治疗勃起功能障碍.
- 需要调查PDI潜在的眼部副作用.
- 塔达拉菲尔是一种广泛处方的PDI.
研究的目的:
- 用光学连贯断层扫描 (OCT) 评估每日使用塔达拉菲尔对后眼部结构的影响.
- 为了评估视网膜厚度,视神经头部和胸腔参数在治疗塔达拉菲尔1个月后的变化.
主要方法:
- 对26名患者进行前性研究,每天使用5毫克的塔达拉菲尔治疗勃起功能障碍.
- 在使用塔达拉菲尔之前和一个月后进行了包括OCT在内的眼科检查.
- 测量包括中枢视网膜厚度 (CRT),状细胞层+内状层 (GCL+IPL),周状视网膜神经纤维层 (pRNFL),光盘参数,胸膜厚度和血管度.
主要成果:
- 在使用塔达拉菲尔后,在任何象限中都没有观察到CRT,GCL+IPL或prNFL厚度的统计学上显著差异.
- 在治疗前和治疗后的访问中,光盘头的测量和胸膜厚度仍然相似.
- 胸腔血管参数,包括光线胸腔区域和胸腔血管指数 (CVI),没有显著变化.
结论:
- 一个月的定期每日使用塔达拉菲尔治疗勃起功能障碍并没有导致测量后眼部结构的显著改变.
- 这些发现表明,塔达拉菲尔在短期内对眼睛的后部安全.
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