非线性进化权衡的出现和遗传多态性维护
Samuel V Hulse1, Emily L Bruns1
1University of Maryland College Park.
bioRxiv : the preprint server for biology
|June 10, 2024
概括
进化性权衡往往承担特定的成本效益功能. 这项研究表明,遗传架构可以产生加速成本,这是一个常见的假设,并揭示了遗传多态化的细微条件.
科学领域:
- 进化生物学是进化的生物学.
- 定量遗传学 是一种定量遗传学.
- 基因组学就是基因组学.
背景情况:
- 量化特征的进化模型依赖于将成本与收益联系起来的权衡函数.
- 权衡函数的选择显著影响模型结果,影响平衡基因型和进化分支.
- 目前还没有一个强大的理论基础来选择权衡函数.
研究的目的:
- 研究遗传架构如何影响进化权衡函数的形状.
- 探索从潜在的遗传机制中出现的权衡函数的出现.
- 为了将基因型级别的特性与宏观进化结果联系起来.
主要方法:
- 开发了一种针对疾病耐药性和生育能力的多部位遗传模型,其中包含了对抗性类型.
- 生成基因型景观来分析添加和表观基因架构对权衡形状的影响.
- 使用这些基因型景观来预测平衡状态,构建了一个进化模型.
主要成果:
- 多地点模型始终产生加速的成本权衡函数,不论表现如何.
- 基于这些衍生的权衡构建的进化模型经常导致在平衡状态下的遗传多态.
- 加速成本似乎是进化权衡的一个强大的零模型.
结论:
- 遗传架构为进化模型中出现的权衡函数提供了基础.
- 在加速成本下有利于基因多态化的条件可能比以前理解的更复杂.
- 这项工作弥合了遗传基础和宏观进化对权衡的预测之间的差距.
更多相关视频
相关概念视频
Mutation, Gene Flow, and Genetic Drift
58.3K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.3K
Genetic Drift
39.7K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.7K
Limits to Natural Selection
31.2K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
31.2K
Gene Flow
35.0K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
35.0K
Genetics of Speciation
19.2K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.2K
Gene Evolution - Fast or Slow?
7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.1K


