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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

706
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
706
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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相关实验视频

Updated: Jun 24, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

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对B细胞克隆家族分配的评估方法

Katalin Voss1, Katrina M Kaur2, Rituparna Banerjee3

  • 1Department of Quantitative and Computational Biology, University of Southern California, USA.

bioRxiv : the preprint server for biology
|June 10, 2024
PubMed
概括
此摘要是机器生成的。

在比较B细胞受体库分析方法时,SCOPer-H优越,但需要生殖基因参考. mPTP方法对缺乏此类参考物种的抗体进化研究具有前景.

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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

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相关实验视频

Last Updated: Jun 24, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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科学领域:

  • 免疫学和生物信息学
  • 适应性免疫反应是一种适应性免疫反应.
  • 分析B细胞受体谱的分析

背景情况:

  • B细胞受体对于适应性免疫至关重要,由VDJ重组产生,并通过体质突变改进.
  • 精确的克隆鉴定对于理解B细胞扩张动态和体质突变模式至关重要.
  • 现有的B细胞克隆鉴定方法缺乏全面的比较分析.

研究的目的:

  • 进行当前B细胞谱分析方法的广泛比较.
  • 评估mPTP (移动性PTP) 遗传学方法对B细胞克隆分配的性能.
  • 在不同的方法中评估克隆分配和祖先状态重建中的错误.

主要方法:

  • 在各种条件下对B细胞谱进行了广泛的模拟.
  • 使用SCOPer-H和mPTP对克隆分配准确性的比较分析.
  • 下游祖先状态重建错误的评估.

主要成果:

  • 在克隆分配的各种参数中,SCOPer-H表现出卓越的性能.
  • 与定制免疫遗传方法相比,mPTP方法的错误率较低.
  • 由于SCOPer-H依赖于生殖系基因组合,因此其在非模型生物体中的适用性受到限制.

结论:

  • 当有生殖系参考资料时,SCOPer-H是一种非常有效的B细胞谱系分析方法.
  • mPTP提供了具有竞争力准确性的可行替代方案,特别是在缺乏参考基因组的物种中进行抗体进化研究.
  • 研究非模型生物中的抗体进化研究的研究人员应该考虑mPTP进行可靠的克隆分析.