在视觉皮层电路内的突触和内在恒温可塑性的模块化排列
Wei Wen1, Adriana M Prada1, Gina G Turrigiano1
1Department of Biology, Brandeis University, Waltham, MA 02453, USA.
bioRxiv : the preprint server for biology
|June 10, 2024
概括
突触缩放和内在的恒常性可塑性 (IHP) 稳定大脑网络. 这些机制可以独立地被招募,这表明一个模块化系统而不是冗余来保持神经网络的稳定性.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 新皮质电路使用恒温可塑性来维持稳定的网络活动.
- 突触缩放和内在的恒常性可塑性 (IHP) 是关键机制,但它们的相互作用尚不清楚.
研究的目的:
- 调查突触缩放和IHP是否有冗余或独立的作用.
- 确定这些机制是否在动物V1 L2/3金字塔神经元中排列分层或模块化.
主要方法:
- 在体外和体内使用药理学和遗传学干扰.
- 操纵神经元激增活动和NMDAR信号.
主要成果:
- 突触缩放和IHP共享信号通路,但可以独立地被招募.
- 视觉体验变化通过影响NMDAR激活而不会改变平均发射,选择性地触发了IHP,而不是突触缩放.
结论:
- 这些发现支持了恒常性可塑性的模块化模型.
- 突触和内在的可塑性独立地对不同的网络活动特征做出反应和稳定.
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