在孤立的REM睡眠行为障碍中,纵向网络变化和光转换风险
David Eidelberg1, Chris Tang1, Yoshikazu Nakano1
1The Feinstein Institutes for Medical Research.
Research square
|June 10, 2024
概括
在孤立的快速眼动睡眠行为障碍 (iRBD) 中的大脑网络的变化预测了帕金森病的发展. 这些网络变化和多巴胺载体 (DAT) 水平可以在症状出现前几年评估表转化风险.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 孤立的快速眼动睡眠行为障碍 (iRBD) 是帕金森病 (PD) 和其他α-synucleinopathies的公认的前兆综合征.
- 了解iRBD的神经基础和进展对于早期诊断和PD干预至关重要.
研究的目的:
- 研究iRBD患者的大脑网络表达和多巴胺转运器 (DAT) 结合的纵向变化.
- 为了确定这些神经成像标记物与帕金森病转化现象风险之间的关系.
主要方法:
- 在基线,2年和4年测量帕金森病相关运动 (PDRP) 和认知 (PDCP) 网络表达的纵向成像研究.
- 评估杜巴胺转运体 (DAT) 在骨中的结合.
- 基于网络进展和DAT损失的现象转换预测模型的开发.
主要成果:
- 随着时间的推移,PDRP和PDCP网络表达都增加了,而PDRP显示了更高的值.
- 最初在PDRP内部局部化的异常功能连接演变为包括桥接PDRP和PDCP的连接.
- 一个整合PDRP进展和Putamen DAT损失的预测模型准确地预测了iRBD个体在1.2年内发生的表态转化.
结论:
- 大脑网络的不适应性重组在iRBD中发生在临床变现前几年.
- 网络表达和DAT结合的综合评估为评估iRBD患者的表转化风险提供了有价值的工具.
- 早期识别网络变化可能使得高患帕金森病风险的个体能够及时进行干预.
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