连接组和和在迷幻DMT下的主观经验之间的时间解决合.
Jakub Vohryzek1,2, Andrea I Luppi1,3,4,5, Selen Atasoy1,6
1Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, United Kingdom.
bioRxiv : the preprint server for biology
|June 10, 2024
概括
像DMT这样的迷幻药物改变了大脑连接模式,类似于psilocybin和LSD. 这项研究将这些大脑变化,特别是连接组波,与吸毒期间主观体验的强度联系起来.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 计算神经科学是一种神经科学.
背景情况:
- 了解大脑的结构和功能网络是解读主观经验的关键.
- 迷幻药调节神经递质系统,提供对感知,认知和意识的见解.
研究的目的:
- 通过连接体和分解的透镜研究N,N-二甲基胺 (DMT) 对大脑功能的影响.
- 确定DMT是否以与其他已知的迷幻药相一致的方式改变大脑的功能表.
- 探索连接组和声调的变化与主观迷幻体验的强度之间的关系.
主要方法:
- 利用连接体和分解,这是一个分析大脑功能对结构连接体组织的依赖的框架.
- 在DMT下分析了大脑活动模式,并将由此产生的连接组和声谱与psilocybin,LSD和ketamine的数据进行了比较.
- 测量了随着时间的推移连接组波的和能量频谱差异.
主要成果:
- 在DMT下,连接组的和曲目显示出显著的重塑,与psilocybin,LSD和ketamine观察到的镜像效应.
- 在DMT下,连接组波的回增加,与其他迷幻化合物相一致.
- 测量能量频谱差异和曲谱与主观体验强度的时间解决方式相关.
结论:
- 像其他迷幻药一样,DMT改变了大脑在结构连接组中的功能组织.
- 该研究确立了大脑网络动态 (连接组波) 和主观迷幻状态的强度之间的直接,时间解决的联系.
- 连接组的和分解为量化幻觉诱导体验的神经相关物提供了有价值的工具.
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