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Updated: Jun 24, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Published on: February 10, 2023

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流体介导的DNA损伤促进了高等级的血清性卵巢癌的发病

Geyon L Garcia, Taylor Orellana, Grace Gorecki

    bioRxiv : the preprint server for biology
    |June 10, 2024
    PubMed
    概括

    经过表观遗传改变的介质干细胞 (hrMSCs) 驱动DNA损伤,并促进输卵管细胞的存活,启动高度血清性卵巢癌 (HGSOC). 这些hrMSC与BRCA1/2突变和衰老有关,这表明HGSOC检测和预防的新目标.

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