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Updated: Jun 24, 2025

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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在估计人口平均多基因得分历史背景下评估ARG估计方法

Dandan Peng1, Obadiah J Mulder1, Michael D Edge1

  • 1Department of Quantitative and Computational Biology, University of Southern California.

bioRxiv : the preprint server for biology
|June 10, 2024
PubMed
概括

人口多基因分数 (PGS) 的准确估计取决于祖先重组图 (ARG) 方法. 对于历史PGS,SINGER在准确性方面表现出色,而像Relate这样的大样本方法对于最近的人口历史更好.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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