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Updated: Jun 24, 2025

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/MHC复合体中的动态质使TCR新抗原选择性成为可能

Jiaqi Ma1,2, Cory M Ayres1,2, Chad A Brambley1,2

  • 1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.

Research square
|June 10, 2024
PubMed
概括

针对癌症新抗原的T细胞受体 (TCR) 特异性是由HLA-A3结合槽内的动态运动决定的. 这些动态运动作为一个门,影响T细胞受体与新抗原结合,而不是野生类型.

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