在肺高血压中,右心室硬化和异质变化:功能机制和功能关系
bioRxiv : the preprint server for biology
|June 10, 2024
概括
肺高血压导致右心室 (RV) 重塑. 增加的原纤维紧张和肌纤维重定向驱动不适应的RV重塑,导致RV失败.
科学领域:
- 心血管研究研究心血管研究
- 生物医学工程 生物医学工程
- 肺部医学 肺部医学
背景情况:
- 肺高血压 (PH) 导致右心室 (RV) 后负荷增加,导致RV功能障碍和失败.
- 在PH中适应不良的RV重塑的机制尚未完全理解.
- RV壁的硬化和异性变化是 RV 扩张性和收缩性损伤的关键因素.
研究的目的:
- 为了研究在PH的RV自由壁 (RVFW) 生物力学改造的多尺度和机械性质.
- 为了将RVFW生物机械改造与RV功能调整相关联.
- 识别关键的纤维级改造事件,使适应性与不适应性RV改造有所区别.
主要方法:
- 使用了轻度 (缺氧) 和严重 (苏根缺氧) 的PH大鼠模型.
- 使用in-vivo和ex-vivo测量量器官水平的量化功能和组织水平的硬度/微观结构.
- 采用多尺度分析和机器学习,将纤维级重塑与器官级功能障碍联系起来.
主要成果:
- RVFW硬化与减少的RV-肺动脉 (PA) 合有很强的相关性.
- 增加的原纤维紧张度是轻度和重度RVFW硬化之间的关键差异.
- 显著的肌纤维重定向导致RVFW组织异性质的丧失.
结论:
- 多尺度生物力学分析显示,原纤维紧张和肌纤维重定向有助于PH的RV适应不良.
- 这些纤维层次的重塑事件导致过度的RV自由壁硬化和RV-PA脱.
- 了解原纤维改造和异构性损失可以更好地了解RV改造中的适应性到不适应性过渡.
更多相关视频
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
169
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
169
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K


