长期存在的严重mpox病例是晚期艾滋病的机会性感染
Matan S Malka1, Melissa Parkinson2, Jason Zucker2
1Medicine, Columbia University, New York, USA.
Cureus
|June 10, 2024
概括
本病例报告详细介绍了一位晚期艾滋病毒患者的长期 (mpox) 感染,尽管接受了抗病毒治疗,但持续超过六个月. 它强调了免疫受损个体中mopox的严重程度以及病毒清除的挑战.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 免疫受损宿主研究
背景情况:
- 晚期艾滋病毒感染对管理机会性病毒性疾病提出了重大挑战.
- 病毒 (mpox) 可以在免疫系统受损的个体中引起严重的,长期的疾病.
研究的目的:
- 报告一个异常长期的mopox感染病例,该病例发生在一个艾滋病毒发病期晚期的患者身上.
- 描述这种独特患者的临床过程,并发症和治疗反应.
- 为了强调mopox在免疫受损人群中的严重程度,并为未来的管理策略提供信息.
主要方法:
- 一个29岁的男性患有先进的艾滋病毒,并确认了mpox.病例报告.
- 临床表现,实验室发现和治疗干预措施的详细文件.
- 在整个感染期内监测病毒载量 (病毒PCR) 和CD4计数.
主要成果:
- 患者经历了六个半月的mopox感染,并有广泛的性,死角性病变.
- 并发症包括急性损伤,多药耐药性细菌感染和呼吸衰竭.
- 尽管接受了抗病毒治疗 (tecovirimat,brincidofovir) 和支持性护理,但该患者仍然为病毒 (MPXV) 呈PCR阳性,周期值 (Ct) 值较低.
结论:
- 具有未被抑制的病毒载量和低CD4计数的高级HIV与长期和严重的mopox感染有关.
- 目前的治疗策略可能不足以清除严重免疫功能低下个体的持续MPXV.
- 进一步的研究对于在艾滋病毒感染者中开发最优化的mpox治疗方案至关重要.
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