药物不良反应的因果关系,严重性,可预防性和可预测性评估尺度:一篇评论
Pramod K Manjhi1, Madhusudan P Singh2, Mukesh Kumar3
1Pharmacology, All India Institute of Medical Sciences, Patna, Patna, IND.
Cureus
|June 10, 2024
概括
药物监测计划通过监测药物不良反应 (ADRs) 来提高药物安全性. 本综述审查了评估ADR因果关系,可预防性和严重性的工具,以提高患者的安全性.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 临床药理学 临床药理学
背景情况:
- 印度药物监测计划 (PvPI) 提高了对药物不良反应 (ADR) 的认识.
- 营销后监测对于识别罕见或长期副作用以及特定患者群体的副作用至关重要.
- 副作用可能导致发病率,住院和治疗费用增加,从而危及患者的安全.
研究的目的:
- 审查和分析各种工具和方法来评估药物不良反应的因果关系,可预防性和严重性.
- 强调因果关系评估在减少副作用发生和与药物相关的风险方面的重要性.
主要方法:
- 审查有关药物监测和ADR评估工具的现有文献.
- 将因果关系评估方法分类为临床判断,算法和概率方法.
- 识别常用的因果关系 (Naranjo算法,WHO-UMC),可预防性和严重性 (Schumock和Thornton,Hartwig和Siegel) 的规模.
主要成果:
- 有许多方法用于评估因果关系,包括瑞典方法,WHO-UMC尺度和Naranjo的算法.
- 没有一个因果关系评估工具被普遍接受为黄金标准.
- 纳兰乔的算法和WHO-UMC尺度经常用于因果关系评估.
结论:
- 有效的药物监测依赖于对副作用的强有力的因果关系,可预防性和严重性评估.
- 对抗药物反应评估工具的持续评估和潜在标准化对于全球药物安全是必要的.
- 该综述概述了可用的方法,以指导临床医生和研究人员评估ADR.
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