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在重症儿科患者中扩展罗注的安全性

Daniel Moas¹, Elber Y Aydin², Jose Irazuzta³

¹Pediatric Critical Care Medicine, University of New Mexico School of Medicine, Albuquerque, USA.

|June 10, 2024

概括

这项研究在接受高剂量普罗波输液的重症儿科患者中没有发现与普罗波相关的输液综合征 (PRIS) 的病例. 需要进一步的多中心研究,以确定在儿科重症监护中使用普罗波的临床建议.

科学领域:

儿科重症监护医学儿科重症监护医学
药理学药理学是指药理学的学科.
麻醉学麻醉学

背景情况:

普罗波是一种广泛使用的镇静剂和麻醉剂,引起了人们对重症儿科患者的普罗波相关输液综合征 (PRIS) 的担忧.
在这个人群中,醇输注的现有安全数据是有限的,特别是超过既定指导方针的剂量和持续时间.

研究的目的:

为了评估在儿科重症监护室 (PICU) 输注普罗波福尔的风险,当在剂量和持续时间超过之前描述的安全参数.
为了确定与严重病症儿童的普罗波福尔输液风险相关的潜在共同变量.

主要方法:

对173名在PICU中接受普罗波的儿科患者进行了回顾性队列分析.
患者被分为两组:接受输液>48小时和接受输液<48小时的患者.
人口统计数据和每日临床变量被收集了长达七天的输液开始后或直到停止.

主要成果:

在这两组中都没有观察到与醇相关的输液综合征 (PRIS) 的病例,尽管醇的平均剂量很高 (>67mcg/kg/min).
与<48小时队列相比,接受输液>48小时的患者表现出更高的疾病严重性得分和更大的血管活性输液支持需求.
两组之间没有发现乳酸盐水平或其他生化参数的显著差异.

结论:

这项试点研究表明,即使在没有观察到PRIS的情况下,在重症儿科患者中输注普罗波福尔的可行性,即使在延长的持续时间和高剂量下也是如此.
这些发现凸显了需要进行更大规模的多中心研究,以巩固在儿科重症监护机构中使用普罗波的临床建议.

关键词:

这是一种酸性症.儿科儿科儿科普罗波福尔 (Propofol) 是一种与propofol相关的输液综合征拉布多米溶解 (rhabdomyolysis) 是一种治疗方法.

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