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Updated: Jun 24, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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微卫星中断诱导的复制产生高度变异的染色体外圆形DNA.

Rujuta Yashodhan Gadgil1, S Dean Rider1, Resha Shrestha1

  • 1Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.

NAR cancer
|June 10, 2024
PubMed
概括

非BDNA微卫星通过依赖复制的机制产生高度突变的染色体外圆形DNA (eccDNA). 这些eccDNAs有助于基因组的不稳定性,并可能在癌症的发展和治疗耐药性中发挥作用.

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