血中阿斯素度与糖尿病病的进展有关
Mingyue Xu1, Chunlin Zhang1, Linlin Zhang1
1Department of Endocrinology, Translational Research of Diabetes Key Laboratory of Chongqing Education Commission of China, Second Affiliated Hospital of Army Medical University, Chongqing, People's Republic of China.
概括
较高的阿斯素水平与糖尿病病 (DKD) 和前-DKD有关,可能由炎症介导. 阿斯素可能在糖尿病中脏损伤的发展中发挥作用.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症.
- 了解DKD进展背后的分子机制对于开发有效治疗方法至关重要.
- 一种新型阿迪波金 (adipokine) 的阿斯普拉辛 (asprosin) 已涉及代谢调节,但其在DKD中的作用尚不清楚.
研究的目的:
- 在患有DKD前和DKD的个体中研究阿斯素表达.
- 检查阿斯素水平与损伤,炎症和代谢参数之间的关联.
- 探索阿斯素在DKD病变发生过程中的潜在作用.
主要方法:
- 参与者被分为糖尿病 (DM),前-DKD和DKD组,基于尿中的白蛋白:肌素比率 (UACr).
- 测量了血中阿斯素水平,以及各种生理和生化标志物.
- 来自Nephroseq数据库的基因表达数据被分析为脏组织.
主要成果:
- 与DM组相比,在DKD前和DKD组中,阿斯素水平显著升高.
- 来自DKD患者的脏组织显示阿斯素基因表达增加.
- 血阿斯素与损伤 (UACr),代谢功能障碍 (禁食胰岛素,HOMA-IR) 和炎症 (G3P) 的标志物呈正相关性,与估计的膜过率 (eGFR) 呈负相关性.
- 阿斯素度独立地与DKD前和DKD相关,但这种关联是由炎症标记物G3P介导的.
结论:
- 血阿斯素与糖尿病患者的损伤有关.
- 炎症似乎是asprosin和DKD之间的关系的一个关键调解者.
- 需要进一步的研究来阐明阿斯素在DKD发展和进展中的确切作用和机制.
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