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离子交换树脂/卡拉基南铜基纳米复合材料:人工神经网络,先进的热力学分析和抗凝剂研究

Sana Haider¹, Sami Ullah¹, Mohsin Kazi²

¹Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.

|June 10, 2024

概括

从卡拉 (CG) 和离子交换树脂 (IER) 合成的新纳米复合材料有效合铜离子 (Cu2+). 这些材料还显示出有前途的体外抗凝剂活性 (ACA),在金属吸附和血液稀释疗法中具有潜在的应用.

科学领域:

材料科学与工程材料科学与工程
环境化学环境化学
生物化学生物化学

背景情况:

碳素 (CG) 和离子交换树脂 (IER) 已因其金属合能力而得到认可.
开发高效的纳米复合材料 (NCs) 用于金属离子吸附和评估它们的生物活性至关重要.

研究的目的:

使用kappa (κ) CG和IERs合成和表征铜离子 (Cu2+) 吸附的纳米复合材料 (NC).
通过统计物理形式主义 (SPF) 和人工神经网络 (ANN) 来研究Cu2+吸附效率.
评估合成的NCs的体外抗凝活性 (ACA).

主要方法:

DMSCH/κ-Cu,DC20H/κ-Cu和IRP69H/κ-Cu纳米复合物的合成.
使用统计物理形式主义 (SPF) 在不同温度 (315-375 K) 和多层感知器 ANNs 的吸附研究.
通过激活部分血栓形成时间 (APTT) 试验进行体外抗凝活性 (ACA) 评估.

主要成果:

关键吸附参数被确定为pH和度;ANN模型显示高精度 (1.0-4.3%的误差).
热力学分析显示自发吸附 (负 ΔG) 与多层吸附.
这些NC表现出不同程度的体外抗凝活性,IRP69H/κ-Cu显示出显著的潜力.

结论:

合成的CG/IER-CuNCs对Cu2+吸附有效,并且具有显著的体外抗凝性质.
SPF和ANN模型准确地预测吸附行为,验证表面特性和相互作用.
需要进一步的研究来阐明这些NCs抗凝剂活性背后的化学机制.

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