Tinospora cordifolia提取物增强了德克斯特罗米多芬的生物可用性:对阿尔茨海默氏病的影响
Praful Kumar Majhi1, Samir Sayyad2, Mahendra Gaur1
1Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha 751029, India.
ACS omega
|June 10, 2024
概括
Tinospora cordifolia茎提取物增强了德克斯特罗梅索芬的生物可用性,提高了其在阿尔茨海默病管理中的有效性. 这种传统医学在临床前模型中显示出对认知增强和神经保护的前景.
科学领域:
- 药理学和传统医学的医学.
- 神经科学与药物开发
背景情况:
- 丁花皮 (Tinospora cordifolia,TCE) 是一种与氧化压力相关的疾病的传统药物.
- 提高德克斯特罗梅索芬 (DEM) 的生物可用性对于阿尔茨海默病 (AD) 治疗至关重要.
- TCE可能会抑制代谢酶,可能增加DEM的生物可用性.
研究的目的:
- 调查TCE在AD管理中增强DEM生物可用性和有效性的潜力.
- 分析TCE植物成分对CYP2D6和CYP3A4酶的抑制作用.
- 在斯科波拉胺诱导的痴呆症模型中验证TCE的治疗潜力.
主要方法:
- 在植物成分抑制CYP2D6和CYP3A4.4的基分析中.
- 对DEM和德克斯特 (DEX) 分析进行LC-MS延长验证.
- 用不同的TCE剂量和网络药理学分析进行的药理动力学研究.
- 在动物痴呆症模型中进行行为和组织病理学评估.
主要成果:
- 与素 (QN) 相比,TCE (100 mg/kg) 增加了2.8倍的DEM/DEX比率.
- 较高的TCE剂量 (400 mg/kg) 显著提高了药理动力学参数和DEM/DEX比率4.7倍.
- 网络药理学确定了TCE的多个AD相关目标.
- 在动物中,TCE表现出比QN+DEM更好的认知改善和过度活动减少.
结论:
- 丁花皮草提取物显著提高了德克斯特罗梅索芬的生物可用性和疗效.
- TCE 具有与阿尔茨海默病相关的神经保护和认知增强特性.
- TCE为AD管理提供了一个有前途的补充治疗策略.
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