基于Poloxamer的混合微粒装载着蒂摩尔或尤金醇用于局部应用
Jana Sedlarikova1, Magda Janalikova2, Pavlina Egner1
1Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 275, 760 01 Zlin, Czech Republic.
ACS omega
|June 10, 2024
概括
装有尤金醇或醇的波洛克萨默粒显示出增强的控制释放性质. 这些混合微粒表现出显著的抗菌和抗菌膜活性,为局部应用提供了创新的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 波洛克萨默是作为药物输送系统使用的多功能聚合物.
- 尤金醇和硫醇具有抗菌性质.
- 开发高效的载体系统对于提高治疗疗效至关重要.
研究的目的:
- 调查波洛克萨默 (P184,P188,P407) 作为欧原醇和醇的载体.
- 为了评估混合Poloxamers对细胞性质的协同效应.
- 评估开发的菌体的抗微生物和抗菌膜活性.
主要方法:
- 微粒参数的表征 (关键微粒度,表面吸附).
- 用于微粒大小分析的动态光散射.
- 数学建模 (Korsmeyer-Peppas,修改了Gompertz) 释放动力学.
- 细菌还原试验和抗生素膜活性测试.
主要成果:
- 混合波洛克萨默 (P188/P407) 证明了与较低的CMC和更高表面吸附的协同效应.
- 封装eugenol/thymol导致小粒细胞大小的减少.
- 波洛克萨米塞尔对S. aureus和E. coli表现出显著的细菌静止活性,混合米塞尔的效果延长.
- 实现了高封装效率 (>90%) 和抗菌膜活性.
结论:
- 波洛克萨默混合菌是优原醇和胆醇的有效载体,增强了它们的特性.
- 发达的菌体具有强大的抗微生物和抗菌膜活性.
- 该系统提供了一种创新的方法,用于局部应用中的受控释放.
更多相关视频
10:53Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
14.0K
07:05Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
Published on: August 23, 2024
1.6K
相关概念视频
Local Anesthetics: Common Agents and Their Applications
434
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
434
Colloids
17.4K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
17.4K
Hand hygiene
3.2K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.2K
