访客血压变化和听力损失之间的年龄特定关联:基于人口的队列研究
Xinyue Guo1, Renjian Sun2, Xiaorui Cui1
1Department of Biostatistics, National Health Commission Key Laboratory of Health Technology Assessment, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China.
Innovation in aging
|June 10, 2024
概括
血压变化 (BPV) 与中年成人听力损失的风险更高有关. 对血压变化的早期干预可能有助于预防50岁以上成年人听力损失.
科学领域:
- 心脏病学 心脏病学
- 听力学 听力学是指听力学.
- 流行病学 流行病学
背景情况:
- 听力损失是一种普遍的疾病,往往未得到充分治疗.
- 血压变化 (BPV) 和听力损失之间的关系尚不清楚.
- 调查特定年龄的关联对于有针对性的干预措施至关重要.
研究的目的:
- 为了检查访问到访问的血压变化 (BPV) 和发展听力损失的风险之间的特定年龄关联.
- 为了确定在哪个年龄段血压变化造成听力损失的最大风险.
主要方法:
- 一项针对美国50岁以上的3939名成年人的全国代表性队列研究 (健康和退休研究).
- 使用标准偏差 (SD),变化系数和三次访问中独立于平均值 (VIM) 的变化评估了静缩血压 (SBP) 和静缩血压 (DBP) 的变化.
- 听力损失通过自我报告进行评估;用于分析的是特定年龄的Cox比例风险模型和通用添加式Cox模型.
主要成果:
- 在65岁以下的成年人中,每增加标准偏差 (SD) 的VIM,就观察到听力损失的风险增加了36%.
- 在年轻人群中,在DBP的VIM和听力损失之间发现了一个略显的关联 (HR per SD 1.21).
- 65岁及以上的成年人没有发现任何显著的关联;年轻的参与者显示出更强烈的BPV-听力损失关联.
结论:
- 较高的间歇性血压变化与中年 (50-65岁) 成人的听力损失风险增加有关.
- 这些发现表明,早期控制血压变化可能是减轻50岁以上成年人听力损失风险的策略.
- 进一步研究将BPV与听力损失联系在一起的机制是有必要的.
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