阿帕胺对前列腺癌患者甲状腺功能的影响
Clare Moffatt1, Melissa G Lechner1, Trevor E Angell2
1Division of Endocrinology, University of California, Los Angeles (UCLA) Geffen School of Medicine, Los Angeles, CA 90095, USA.
Journal of the Endocrine Society
|June 10, 2024
概括
阿帕胺 (APT) 可以导致前列腺癌患者的甲状腺功能低下,往往需要增加甲状腺激素的替代. 甲状腺功能监测在APT治疗期间和之后至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿帕胺 (APT) 是一种用于治疗前列腺癌的非类固醇抗雄激素.
- 甲状腺功能障碍是APT已知的不良影响,但其临床表现和管理仍未得到充分研究.
研究的目的:
- 研究前列腺癌患者的阿帕胺相关甲状腺功能障碍的临床表现和治疗策略.
主要方法:
- 分析了16名用阿帕胺治疗前列腺癌的患者的病例系列.
- 评估了临床参数,甲状腺功能测试和甲状腺激素需求.
主要成果:
- 16名患者在APT治疗期间发生甲状腺功能低下症 (新发或恶化),异常在2至4周后就出现.
- 用levothyroxine (LT4) 替代甲状腺激素是有效的,尽管一些患者需要更高的剂量.
- 在停止APT后,甲状腺激素水平正常化,激素需求下降.
结论:
- 阿帕胺诱导的甲状腺功能障碍呈现为甲状腺功能低下症,需要甲状腺激素替代或剂量调整.
- 在APT治疗期间和治疗后,建议定期监测甲状腺功能测试.
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