腹碳水化合物抗原50和恶性腹液:一个潜在的,双盲的诊断准确性测试
Su-Na Cha1,2, Yan Niu3, Jian-Xun Wen3
1Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Translational lung cancer research
|June 10, 2024
概括
斑膜液碳水化合物抗原50 (CA50) 在诊断恶性斑膜溢出 (MPE) 中显示了中度的准确性. 将CA50与癌胚抗原 (CEA) 结合起来,可以提高MPE的诊断灵敏度.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 血清碳水化合物抗原50 (CA50) 是一种辅助瘤标记物.
- 腹液CA50用于诊断恶性腹液 (MPE) 的实用性尚未得到充分证实.
研究的目的:
- 为了评估MPE的肺部液CA50的诊断准确性.
- 评估CA50在患有未确定的原因的多流的患者中的作用.
主要方法:
- 一项针对153名患有多流的患者的前性研究.
- 使用电化学发光测定测量液CA50和癌胚抗原 (CEA).
- 通过接收器操作特征 (ROC) 曲线分析和决策曲线分析 (DCA) 评估的诊断准确性.
主要成果:
- 恶性流 (MPE,n=66) 显示CA50和CEA水平明显高于良性流 (BPE,n=87).
- 胸腔液CA50实现了0.72.7的ROC曲线下的面积 (AUC).
- 在15 IU/mL的值下,CA50对MPE表现出30%的灵敏度和100%的特异性,确定了一些CEA或细胞学错过的病例.
结论:
- 胸腔液CA50提供了适度的诊断准确性和检测MPE的净益.
- 胸腔液CA50水平>15 IU/mL可以帮助诊断MPE.
- 将CA50与CEA结合起来可以提高MPE的诊断灵敏度.
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