血液培养的阳性时间导致候选血病及其与死亡率的关系
Arun Sachu1, Sanjo Sunny2, Philip Mathew2
1Department of Micobiology, Believers Church Medical College, Thiruvalla, Kerala, India.
Iranian journal of microbiology
|June 10, 2024
概括
阳性时间 (TTP) 可以帮助区分血流感染中的Candida物种. 较短的TTP可能表明对可纳敏感的Candida tropicalis,而较长的TTP可能表明耐可纳的Candida glabrata.
科学领域:
- 医学真菌学 医学真菌学
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
背景情况:
- 早期诊断候选血症对于降低死亡率和发病率至关重要.
- 坎迪达菌血流感染带来了重大的临床挑战,特别是随着抗真菌耐药性的增加.
研究的目的:
- 为了确定各种导致血流感染的Candida物种的阳性化时间 (TTP).
- 评估TTP是否可以区分抗可纳的Candida glabrata与对可纳敏感的Candida物种.
主要方法:
- 血液培养物被分析为TTP和适当的抗真菌疗法 (AAT).
- 评估了血病的危险因素,包括长时间的ICU住院和导管使用.
- 针对特定的Candida物种计算了TTP的诊断灵敏度.
主要成果:
- 所有Candida分离物的TTP中位数为34小时.
- 在TTP检测中,Candida glabrata的灵敏度为88%,Candida tropicalis的灵敏度为85%.
- 根据TTP (<24小时与>24小时) 或抗真菌疗法启动时间,没有观察到生存时间的显著差异.
结论:
- 较长的TTP可能预测Candida glabrata,而较短的TTP可能表明Candida tropicalis.
- 如果TTP为<48小时,则对可纳耐药的Candida血流感染的可能性较小.
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