在改善不同卵巢反应的患者的妊娠结果中,HCG触发器与双触发器的比较:一项回顾性研究
Ke Xu1,2,3,4, Jinrong Wang1,5, Shuangshuang Yang3,6
1Center for Reproductive Medicine, Shandong University, Jinan 250012, Shandong, China.
International journal of endocrinology
|June 10, 2024
概括
在体外受精-胚胎移植 (IVF-ET) 中的双触发方案改善了卵细胞产量,并降低了正常和高响应者的OHSS风险,而不会影响怀孕结果. 这种方法不推给反应较差的人,强调个性化的IVF-ET策略.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 触发日血清雌激素 (E2) 水平对于体外受精-胚胎移植 (IVF-ET) 成功至关重要.
- 优化排卵诱导和卵细胞检索是改善IVF-ET怀孕率的关键.
研究的目的:
- 在IVF-ET患者中,比较双触发和单触发方案之间的妊娠结果.
- 为了评估不同卵巢反应组的不同触发方案的疗效.
主要方法:
- 对1032名接受IVF-ET与对抗剂治疗方案的不育患者的回顾性分析.
- 根据卵巢反应,患者被分为单触发和双触发组.
主要成果:
- 双触发疗法增加了正常/高响应者的卵细胞计数和获得率,减少了与OHSS相关的取消.
- 对于正常/高响应者的治疗方案之间没有观察到怀孕或活产率的显著差异.
- 双触发器疗法显示了更高的E2水平,并降低了OHSS风险,而不会影响正常和高响应者的结果.
结论:
- 双触发方案在IVF-ET中对正常和高响应者有效,为单触发方案提供与单触发方案相比的妊娠结果,同时减轻OHSS风险.
- 该研究表明,双触发方案可以替代单触发方案的正常/高响应者.
- 基于卵巢反应的个性化治疗至关重要,需要对内分泌参数影响进行进一步的研究.
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