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Updated: Jun 24, 2025

Xenopus laevis as a Model to Identify Translation Impairment
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一个5' UTR语言模型用于解码mRNA的未翻译区域和功能预测

Yanyi Chu1,2, Dan Yu3, Yupeng Li3

  • 1Center for Statistics and Machine Learning and Department of Electrical and Computer Engineering, Princeton University, Princeton, NJ 08544, USA.

Nature machine intelligence
|June 10, 2024
PubMed
概括

一个新的语言模型,UTR-LM,准确预测5'未翻译区域 (UTR) 功能,提高翻译效率和蛋白质表达. 这种人工智能工具显著改善了对核糖体负载的预测,并确定了新的监管元素.

关键词:
5未翻译的地区基因表达的基因表达方式内部核糖体的入口点是内部核糖体的入口点.语言模型语言模型它们是mRNARNA.核糖体负荷是指核糖体负荷.自主监督学习学习翻译效率 翻译效率 翻译效率

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Regulated mRNA Transport02:22

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In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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