在COVID-19后的长期嗅觉损失:病理生物学和潜在的治疗策略
Sarah Kim1, John B Finlay2, Tiffany Ko3
1Department of Head and Neck Surgery & Communication Sciences Duke University Durham North Carolina USA.
有相当数量的COVID-19患者经历了急性气味丧失. 持续的嗅觉功能障碍,包括帕洛斯米亚,影响着数以百万计的人,突显了对这种长期的COVID症状有效治疗的迫切需要.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 急性嗅觉丧失 (无味症) 是SARS-CoV-2感染的常见早期症状.
- 虽然大多数人康复了,但5-10%的人患有持续的嗅觉功能障碍,包括鼻.
- 这种未得到满足的医疗需求影响着数以百万计的COVID-19后患者.
研究的目的:
- 要总结SARS-CoV-2引起的嗅觉损失的病理生物学.
- 探索长期COVID嗅觉功能障碍的机制.
- 审查当前和未来的治疗策略,以恢复嗅觉.
主要方法:
- 审查目前对SARS-CoV-2与外周嗅觉系统相互作用的理解.
- 探索持续的嗅觉功能障碍的病理生物学模型.
- 现有和新兴的治疗方法的总结.
主要成果:
- SARS-CoV-2 直接影响周围嗅觉系统,导致急性气味丧失.
- 在长期COVID中持续的嗅觉功能障碍可能涉及未解决的免疫细胞活性.
- 目前,针对COVID后嗅觉功能障碍的有效治疗方法有限.
结论:
- 了解病毒相互作用和免疫反应对于治疗嗅觉功能障碍至关重要.
- 迫切需要对治疗策略进行进一步的研究,以应对长期COVID气味丧失影响的数百万患者.
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