使用心理物理评估的持续后COVID-19嗅觉功能障碍的恢复率:一个纵向队列研究
Jeremy P Tervo1, Patricia T Jacobson2, Brandon J Vilarello1
1Columbia University Vagelos College of Physicians and Surgeons New York New York USA.
概括
在COVID-19后持续的嗅觉功能障碍 (OD) 仍然很常见,许多患者一年后出现缺陷. 在嗅觉检测值方面出现了改善,而不是识别或歧视.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 持续的嗅觉功能障碍 (OD) 是SARS-CoV-2感染的显著后果,影响长期COVID患者.
- 目前对持久性OD的理解严重依赖于自我报告的症状,客观评估的纵向数据有限.
- 标准化心理物理测试对于准确的患者咨询对于COVID-19后嗅觉恢复至关重要.
研究的目的:
- 在COVID-19后的患者中量化持续的嗅觉功能障碍的程度.
- 为了比较主观的嗅觉报告与客观的心理物理评估随着时间的推移.
- 为了评估COVID-19感染后一年的嗅觉功能的纵向恢复率.
主要方法:
- 参与者有COVID-19病史和嗅觉功能障碍的人被录取.
- 嗅觉功能在基线和1年后使用视觉模拟秤和Sniffin' Sticks扩展试验进行了评估.
- 参与者根据主观和心理物理嗅觉状态被分为队列.
主要成果:
- 在122名基线参与者中,53人完成了1年的随访.
- 在基线时,74.5%的被认为有OD的参与者显示出已确认的心理物理OD,在1年后降至55.1%.
- 总的TDI得分提高了3.25分 (p=0.0005),这是由于值的改善 (+2.75分;p=0.0004).
结论:
- 嗅觉功能障碍在COVID-19后的大量人群中仍然存在,缺陷在1年后明显.
- 嗅觉值的改善有助于整体TDI得分的恢复,而歧视和识别能力的变化较小.
- 客观,纵向的心理物理数据对于了解和管理SARS-CoV-2感染后持续的嗅觉功能障碍至关重要.
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