脑脊髓液通过静脉上的动态细胞毛孔流出,作为大脑排水系统中缺失的部分
Yaqiong Dong1,2, Ting Xu2, Lan Yuan2
1Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine Qingdao University Qingdao China.
Exploration (Beijing, China)
|June 10, 2024
概括
研究人员发现了一种新的脑废物清理途径,通过 venules 中的喇形孔. 这一发现更新了淋巴系统模型,并可能解释阿尔茨海默病 (AD) 的病理学.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
背景情况:
- 淋巴系统清理大脑的废物,其功能障碍与阿尔茨海默病 (AD) 有关.
- 目前的模型还不能完全解释脑脊液 (CSF) /间歇液 (ISF) 溶液流出机制.
研究的目的:
- 为了阐明淋巴清除的完整机制.
- 为了确定CSF/ISF溶解物流出脑膜到血液的新途径.
主要方法:
- 实时,体内观察溶液流量.
- 研究了Zn2+在血管内皮细胞紧接口重建和孔隙形成中的作用.
主要成果:
- 发现了一种新的排水通路,涉及动态组装的大脑静脉壁上的喇形孔.
- 观察到CSF分子通过这些毛孔直接进入血液.
- Zn2+诱导的紧接口重建可能有助于孔隙形成.
- 在AD模型小鼠中观察到粉样β (Aβ) 通过这些毛孔的缺陷清除.
结论:
- 建议对淋巴清除及其调节进行更新模型.
- 通过这些静脉孔的脑排水受损可能会导致AD中的Aβ积累.
- 在阿尔茨海默病中,周血管空间的致病扩张可能与淋巴功能受损有关.
相关概念视频
Cerebrospinal Fluid
2.1K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
2.1K
The Blood-brain Barrier
47.2K
Overview
47.2K
Anatomy of the Brain: Ventricles
3.9K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
3.9K
Transcellular Transport of Solutes
3.5K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
3.5K
Veins of Head and Neck
1.7K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
1.7K
Fluid Movement Between Compartments
508
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
508


