精神分裂症中的同理心:在情绪识别和情感分享期间的神经改变
Simon Knobloch1,2,3, Delia Leiding1, Lisa Wagels1,4
1Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, Germany.
Frontiers in psychiatry
|June 10, 2024
概括
精神分裂症患者在视觉处理方面表现出微妙的行为缺陷,但在大脑活动中显示出显著的差异,特别是在情绪网络中. 右前面的胰岛与这些异常的神经模式有关,这表明神经反干预的潜力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症 (SCZ) 的特点是情绪识别和处理的缺陷.
- 了解这些缺陷的神经支对于开发有效的治疗方法至关重要.
研究的目的:
- 通过功能磁共振成像 (fMRI) 来研究SCZ患者的情绪识别和情感共享.
- 探索SCZ的行为表现,神经激活和临床症状之间的关系.
主要方法:
- fMRI用于扫描22名SCZ患者和22名健康对照 (HC) 在静态和动态面部刺激任务期间.
- 任务包括情绪识别,年龄歧视和情感分享.
- 评估了当前的症状和认知缺陷.
主要成果:
- SCZ患者在年龄歧视方面表现出延长的反应时间,但在情绪处理方面没有行为缺陷.
- 在静态情绪识别过程中,在前带状皮质 (ACC) 和右前半岛 (AI) 中观察到减少激活.
- 在情感共享期间,关键的同理心区域的异常激活,包括尾状核,右人工智能,下额前环 (IFG),小脑和丘脑.
结论:
- SCZ患者在复杂的视觉处理中表现出行为缺陷,无论情绪内容如何,在情绪处理网络中出现异常的神经激活.
- 正确的AI在整合这些网络中发挥着关键作用,并为神经反疗法提供了潜在的目标.
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