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免疫检查点受体巨/单细胞的表达,以应对急性病毒性呼吸道感染

Asmaa Zahran¹, Hosni A Hussein², Ali A Thabet³

¹Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Journal of clinical medicine research

|June 10, 2024

概括

在患有急性病毒性呼吸道疾病的患者中,巨细胞表现出改变的表型和两极分化. 巨细胞亚型中的这些变化与炎症标志物相关,并表明病毒感染的潜在治疗点.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
病毒学病毒学

背景情况:

包括COVID-19在内的急性病毒性呼吸道疾病涉及复杂的免疫反应.
巨细胞在病毒感染期间的宿主防御和炎症中发挥着关键作用.
了解巨细胞两极分化对于控制疾病进展和开发治疗方法至关重要.

研究的目的:

研究急性病毒性呼吸道疾病患者的巨细胞的表型变化和两极分化.
为了比较患者和健康对照的巨细胞亚群.
为了确定巨细胞亚型和炎症指数之间的相关性.

主要方法:

来自27名患者和健康对照的外周血液样本的流细胞计分析.
使用BD FACSCanto II分析仪,使用三种激光进行详细的细胞分析.
各种巨细胞和单细胞亚群的量化百分比.

主要成果:

与对照组相比,患者的CD11B+CD68+巨细胞和特定的M1 (CD274+) 和M2 (CD274+,CD80-CD206+) 亚型的积累增加.
健康对照组显示CD273+M2,CD80+CD206-M1和CD80+CD86+M1巨细胞的表达更高.
在患者和对照组之间观察到巨细胞亚型分布的显著差异 (P <0.05).

结论:

巨细胞功能障碍有助于提高免疫活性和炎症在病毒性呼吸道感染.
变化的巨细胞极化是病毒性疾病的标志,表明潜在的治疗目标.
免疫检查站在病毒性呼吸道疾病的严重病例中代表了免疫调节的有希望的途径.

关键词:

急性呼吸道病毒感染.在CD273+ M1中使用.在CD273+ M2中使用.在CD274+ M1中使用.在CD274+ M2中使用.巨细胞是一个巨细胞.

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