含有基连体的Pd(II) 复合物的结构特征和抗增殖活性:希夫基和减少的希夫基复合物的比较研究
Kimia Forooghi1, Hadi Amiri Rudbari1, Claudio Stagno2
1Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran. h.a.rudbari@sci.ui.ac.ir.
Dalton transactions (Cambridge, England : 2003)
|June 10, 2024
概括
这项研究合成和表征了新型 ((II) 复合物与基联体,揭示了它们作为蛋白酶体抑制剂和抗增殖剂对抗白血病细胞系的潜力. 金属离子是金属离子.
科学领域:
- 协调化学 协调化学
- 有机金属化学 有机金属化学
- 药用化学 医学化学
背景情况:
- 帕拉 (II) 复合体因其多样化的生物活动而被探索.
- 希夫基联体及其缩小形式提供了多样化的协调环境.
- 化联体可以调节金属复合物的特性.
研究的目的:
- 合成和表征新型 (II) 复合物,其中含有不同基希夫基和减少的希夫基联结物.
- 研究这些Pd (II) 综合体的结构特征和抗扩散活性.
- 通过蛋白质酶抑制和对接研究来阐明作用机制.
主要方法:
- 使用光谱方法 (例如,UV-Vis) 和X射线晶体学合成和描述Pd(II) 复合物.
- 使用TD-DFT进行光谱分析的计算研究.
- 针对白血病细胞系的蛋白质酶抑制 (度) 和抗增殖活性 (瑞沙苏林方法) 的体外试验.
- 对蛋白质体和DNA进行分子对接研究.
主要成果:
- Pd(II) 复合体呈现出扭曲的正方形平面几何形状,具有不同的连接体协调模式.
- TD-DFT计算提供了对影响UV-Vis光谱的电子转换的见解.
- 所有合成的复合物都表现出显著的蛋白酶体抑制 (IC50在低微分子范围) 和对白血病细胞的抗增殖作用 (IC50在亚微分子到低微分子范围).
- 抑制活性与离子的存在密切相关.
结论:
- 合成的 (II) 复合物具有有希望的蛋白质酶抑制和抗增殖特性.
- 连接体中的结构变化会影响协调模式和潜在的生物活性.
- 这些复合物代表了作为抗癌剂进一步开发的潜在候选者,其机制可能涉及蛋白质酶抑制.
更多相关视频
07:20Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.0K
10:42Combining Solid-state and Solution-based Techniques: Synthesis and Reactivity of ChalcogenidoplumbatesII or IV
Published on: December 29, 2016
10.7K
相关概念视频
02:42Valence Bond Theory
8.5K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
8.5K
02:34Structural Isomerism
19.2K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.2K
01:22EDTA: Chemistry and Properties
1.9K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
1.9K
02:51Metal-Ligand Bonds
20.7K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.7K
02:46Crystal Field Theory - Tetrahedral and Square Planar Complexes
42.3K
Tetrahedral Complexes
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
42.3K
00:43Complexometric Titration: Ligands
945
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
945