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Updated: Jun 24, 2025

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内皮细胞的sphingosine 1-phosphate受体1抑制VE-cadherin裂变,并减轻实验性炎症性关节炎

Nathalie Burg1, Ryan Malpass1, Linda Alex1

  • 1Hospital for Special Surgery, New York, New York, USA.

JCI insight
|June 10, 2024
PubMed
概括

内皮细胞的sphingosine 1-phosphate受体1 (S1PR1) 在风湿性关节炎中保持血管屏障的完整性. 破坏EC S1PR1信号增加了血管泄漏和关节损伤,突出了S1PR1作为治疗点.

关键词:
关节炎是一种关节炎.内皮细胞是内皮细胞.炎症 炎症是一种炎症.血管生物学 血管生物学

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