在人体液中对乙氨基,可代因和咖啡因的同步分析,采用石墨印电极
Bahaa G Mahmoud1, Mustafa J A Abualreish2, Mohamed Ismael1
1Department of Chemistry, Faculty of Science, Sohag University, 82524, Eqypt. mohamed.khairy@science.sohag.edu.eg.
Analytical methods : advancing methods and applications
|June 10, 2024
概括
本研究介绍了一种简单的电化学方法,用于同时检测乙氨基 (ACP),代 (COD) 和咖啡因 (CAF),使用丝印电极. 在硫酸中优化的方法为分析这些药物在制药配方和生物流体中提供了灵敏和可靠的方法.
科学领域:
- 分析化学 分析化学
- 电化学 电化学 电化学
- 药品分析 药品分析
背景情况:
- 准确量化诸如乙氨基 (ACP),代 (COD) 和咖啡因 (CAF) 等药品对于质量控制和治疗监测至关重要.
- 现有的同时药物分析方法可能是复杂和耗时的.
- 开发快速,灵敏和经济高效的电化学传感器是非常理想的.
研究的目的:
- 开发一种简单的电化学方法,用于同步确定ACP,COD和CAF.
- 调查使用未经修改的丝印电极 (SPEs) 进行同时药物分析.
- 优化支电解质和分析条件,以提高传感性能.
主要方法:
- 使用未经修改的丝网打印电极 (SPEs) 进行电化学分析.
- 对各种辅助电解质 (H2SO4,HCl,H3PO4,BR) 的研究. 缓冲器). 这是一个缓冲器.
- 电压测量测量以确定ACP,COD和CAF度.
主要成果:
- 一个0.05mol L-1硫酸溶液被确定为最优的支持电解质.
- 该方法实现了ACP的线性度范围为3.0-35.0μmol L-1,COD为10-160μmol L-1,CAF为10-160μmol L-1.
- 获得了低检测极限 (3S/N):ACP的L-1为0.9μmol,COD的L-1为4.8μmol,CAF的L-1为6.3μmol.
结论:
- 拟议的电化学方法提供了一种简单,快速和敏感的方法,用于同时确定ACP,COD和CAF.
- 未经修改的SPEs对于这些药物的电分析传感是有效的.
- 该协议显示了在线监测人体液体中的药物配方和药物的潜力,并得到了令人满意的恢复.
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