不同增殖调节胚胎轴延伸期间的多组织形态发生:整合粘性建模和实验方法
Michèle Romanos1,2,3, Tasha Salisbury4,5, Samuel Stephan1
1Molecular, Cellular and Developmental Biology Unit (MCD, UMR 5077), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France.
概括
胚胎组织的不同生长速度显著影响胚胎形状. 我们的研究表明,控制向性中皮细胞增殖会影响神经管和整体体长度.
科学领域:
- 发育生物学是发展生物学.
- 生物物理学的生物物理.
- 计算建模计算建模
背景情况:
- 胚胎发育依赖于协调的组织生长和机械相互作用.
- 神经管和双轴半皮的延长塑造了脊椎动物的身体.
- 同时生长和机械力量对胚胎形态发生的联合影响仍然不完全理解.
研究的目的:
- 调查差异生长,生物物理性质和机械相互作用在轴延伸过程中对胚胎形态发生的影响.
- 阐明不同组织增殖率在形成胚胎结构中的作用.
主要方法:
- 基于连续性的2D多组织数学模型的开发.
- 模拟胚胎轴延伸动力学.
- 模型预测与鸟类胚胎体内时间延迟成像的比较.
- 实验验证使用带有变化的抛向性中皮细胞增殖率的长胚胎进行实验验证.
主要成果:
- 数学模型准确地捕捉了体内观察到的胚胎动态.
- 不同的组织增殖速率对形态发生产生显著,但往往被低估的影响.
- 降低向性介质体中的细胞增殖改变了组织动态和向性介质体和神经管的形状.
结论:
- 不同生长和机械相互作用是胚胎形态发生的关键因素.
- 组织增殖率在确定长期胚胎形状方面发挥着关键作用.
- 该研究提供了一个理论框架,以了解差异增长和发展过程中的机械力量的后果.
更多相关视频
06:49Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
Published on: January 12, 2022
3.2K
08:25Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
Published on: June 2, 2020
9.3K
相关概念视频
Gastrulation
57.2K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.2K
Cellular Differentiation
2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
2.6K
Zygotic Development And Stem Cell Formation
5.1K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.1K
Determination
18.4K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.4K
Morphogenesis
28.1K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.1K
Determining the Plane of Cell Division
3.3K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.3K
