在ADAPT-2试验中,扩展观察了减少使用甲基胺与联合纳尔特雷加布罗的使用量
Michael J Li1,2, Brendon Chau3, Thomas Belin3
1Center for Behavioral and Addiction Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Addiction (Abingdon, England)
|June 10, 2024
概括
延长释放注射性纳尔特雷克松加上口服布洛 (NTX + BUPN) 显著减少了甲基胺的使用. 与安慰剂相比,持续12周的NTX + BUPN治疗导致更高的戒断率.
科学领域:
- 成 药物 药物 药物 药物
- 药物治疗 药物治疗
- 临床试验 临床试验
背景情况:
- 甲基胺使用障碍 (MA) 是一个重要的公共卫生问题.
- 需要新的药物疗法来改善治疗结果.
- 在ADAPT-2试验中,研究了MA使用障碍的组合疗法.
研究的目的:
- 为了评估延长释放注射纳尔特雷加延长释放口服布罗 (NTX + BUPN) 对甲基胺使用障碍的疗效.
- 分析与安慰剂相比,持续NTX + BUPN治疗12周的影响.
主要方法:
- 关于NIDA ADAPT-2网络试验的二次分析.
- 包括403名患有MA使用障碍的参与者.
- 尿液药物查测量了MA使用每两周一次,持续12周,在第13周和第16周进行随访.
主要成果:
- 在12周内,NTX + BUPN组的MA阴性测试增加了27.1%.
- 安慰剂组在12周内显示MA阴性测试增加了11.4%.
- 在NTX + BUPN组中,MA戒断的增加显著更大 (15.8%).
结论:
- 在6周后继续使用NTX + BUPN治疗与MA使用的进一步减少有关.
- 与NTX + BUPN的组合疗法在治疗甲基胺使用障碍方面表现有前途.
- 这项研究支持使用延长释放NTX + BUPN用于持续的MA戒断.
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