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萨卡里纳日本菌的多糖抑制高脂肪饮食引起的肥胖,调节肠道微生物群的组成和功能

Sijia Wang^1,2, Zixi Fu¹, Weibing Chen¹

¹College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Moganshan Research Institute at Deqing County Zhejiang University of Technology, Zhejiang University of Technology, Hangzhou, 310014, China.

Chemistry & biodiversity

|June 10, 2024

概括

日本糖的多糖 (SJPs) 通过调节肠道微生物群,有效打击高脂肪饮食 (HFD) 引起的肥胖症. 该研究确定了在小鼠中改善代谢功能障碍并恢复肠道微生物平衡的特定SJP分离物.

科学领域:

海洋生物技术海洋生物技术
营养科学营养科学
微生物学微生物学

背景情况:

高脂肪饮食 (HFD) 诱导的肥胖是一个越来越严重的健康问题.
肠道微生物群失调与肥胖和代谢障碍有关.
日本糖的多糖 (SJPs) 显示出调节肠道健康的潜力.

研究的目的:

调查不同SJP分量的结构-活动关系.
评估SJPs在缓解HFD诱导的肥胖和葡萄糖代谢功能障碍方面的有效性.
分析SJPs对肠道微生物群组成和功能的影响.

主要方法:

来自Saccharina japonica的五个不同的SJP分数的制备.
在C57BL/6J小鼠口服SJPs时,小鼠被养为HFD.
评估肥胖指标,葡萄糖代谢和肠道微生物群组成 (系和物种水平).

主要成果:

通过口服SJP抑制HFD诱导的肥胖和改善葡萄糖代谢.
最低分子量分数Sj-T-2对抗肥胖最有效.
SJPs调节了肠道微生物群,丰富了有益的细菌 (例如,Desulfobacterota) 并抑制了有害的细菌 (例如,Bacteroidota).
SJPs恢复了肠道微生物的组成,改变了碳水化合物代谢酶的功能.

结论:

肥胖患者在预防和治疗肥胖方面具有显著的潜力.
通过调节肠道微生物群,SJP分量可以恢复肠道平衡.
了解SJP结构-活动关系可以导致有针对性的肥胖干预.

关键词:

16S rRNA 测序的测序方法萨卡里纳日本的多糖化合物我们的肠道微生物群.有高脂肪的饮食.代谢障碍代谢障碍代谢障碍

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