对于抗压力诱导的而言,Lactobacillus rhamnosus GG的剂量依赖的保护作用
Musab Işık1, Cansu Özbayer2, Dilek Burukoğlu Dönmez3
1Department of Physiology, Sakarya University, Medical Faculty, Sakarya, Turkey.
Journal of the science of food and agriculture
|June 10, 2024
概括
在老鼠中,Lactobacillus rhamnosus GG (LGG) 显示出对压力诱导的的保护作用. 这种益生菌可以减少胃出血和炎症,为胃治疗提供一种潜在的天然替代方案.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与压力相关的疾病,特别是的发病率不断上升,需要更安全的治疗替代方案.
- 压力诱导的粘膜出血是重症患者的关键并发症.
- 质子抑制剂有有害的副作用,突出了对自然治疗的需要.
研究的目的:
- 在大鼠中研究Lactobacillus rhamnosus GG (LGG) 对寒冷限制压力诱导的的剂量依赖性保护作用.
- 评估LGG对氧化应激标志物和胃粘膜完整性的影响.
主要方法:
- 一项涉及42只大鼠的研究分为控制,压力,潘托普拉和不同的LGG剂量组.
- 使用ImageJ软件对部区域进行定量分析.
- 测量葡萄糖皮质体,甲基酶 (CAT),超氧化物脱酶 (SOD),谷氨过氧化酶 (GPx) 和马隆迪化物水平.
- 胃组织的组织病理学检查.
主要成果:
- 使用LGG显著增加了CAT,SOD和GPx水平.
- LGG可以防止过度激活下丘脑-垂体-上腺轴.
- 胃粘膜的和出血减少,并观察到乳腺细胞的稳定.
结论:
- 乳酸菌菌GG (LGG) 在减轻与压力相关的胃肠道问题方面显示出潜在的益处.
- LGG可以预防病并降低压力诱导的胃肠道出血的风险.
- 研究结果表明,LGG是一种有前途的天然治疗剂,特别是在重症监护病房患者中.
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