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Updated: Jun 24, 2025

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
08:45

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

Published on: September 7, 2011

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从X射线晶体结构到使用碳酸同酶作为模型系统的蛋白质-连接体结合的内在热力学

Vaida Paketurytė-Latvė1, Alexey Smirnov1, Elena Manakova2

  • 1Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, 10257 Vilnius, Lithuania.

IUCrJ
|June 10, 2024
PubMed
概括

研究人员探索了1000多种硫胺,以了解它们与碳酸酶 (CA) 酶的结合. 这项研究有助于开发针对CA IX的新型抗癌药物,该药物对缺氧瘤至关重要.

关键词:
在X射线晶体学.具有约束力的测定.碳酸无水化酶同酶酶.发现药物的发现.分子间相互作用的分子间相互作用.内在热力学是固有的热力学.分子识别分子识别蛋白质结构 蛋白质结构蛋白质连接和结合

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