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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
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[68Ga]Ga-FAPI-46的自动放射合成用于常规临床使用
Laurence Morandeau1, Joseph A Ioppolo2, Eva Alvarez de Eulate3
1Radiopharmaceutical Production and Development Centre (RAPID), Medical Technology and Physics Department, Sir Charles Gairdner Hospital; laurence.morandeau@health.wa.gov.au.
Journal of visualized experiments : JoVE
|June 10, 2024
概括
自动合成-68标记为纤维细胞激活蛋白抑制剂 (Ga-FAPI-46) 已被开发用于临床正子发射断层扫描 (PET) 成像. 这种方法为癌症诊断提供了高产量和纯度.
科学领域:
- 放射化学 放射化学是指辐射化学.
- 核医学是一种核医学.
- 在瘤学瘤学.
背景情况:
- 纤维细胞激活蛋白 (FAP) 图像使用正子发射断层扫描 (PET) 标记器,如Ga-FAPI-46显示各种癌症的承诺.
- 与FDG-PET相比,FAPI-PET提供了优势,包括没有禁食或休息要求.
- 与早期的FAPI标记剂相比,Ga-FAPI-46表现出优越的药理动力学特性和图像对比.
研究的目的:
- 为临床应用开发和验证Ga-FAPI-46的自动合成.
- 优化反应条件和净化方法,以提高生产效率.
主要方法:
- 使用iPHASE MultiSyn合成器开发了Ga-FAPI-46的自动合成方法.
- 优化反应时间和评估四个固相提取 (SPE) 子用于净化.
- 生产参数的验证,用于生成 0.6-1.7 GBq 的追踪器.
主要成果:
- 自动合成在25分钟内实现了89.8 ± 4.8% (n=6) 的衰变校正产量.
- 最终产品符合所有质量控制规格.
- 合成的Ga-FAPI-46在合成后长达3小时保持稳定.
结论:
- 一种高效可靠的Ga-FAPI-46自动合成方法已被建立用于临床使用.
- 这种自动化过程促进了在瘤学中用于FAP向PET成像的高质量的Ga-FAPI-46的常规生产.
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