艾滋病毒感染者的CD4 nadir和神经认知轨迹
Razmig Garabet1,2, Will Dampier1,2, Shinika Tillman2,3
1Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Journal of neurovirology
|June 10, 2024
概括
艾滋病毒感染者的CD4最低值低并不能预测长期的神经认知能力下降. 语言流性可能会随着时间的推移而改善,即使是在CD4的最低点低之后,这表明治疗的好处.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 人类免疫缺陷病毒相关的神经认知障碍 (HAND) 持续存在,尽管结合抗逆转录病毒疗法.
- CD4 nadir是已知的横截面认知的预测指标,但其对特定神经认知领域的纵向影响尚不清楚.
研究的目的:
- 在特定领域研究CD4底和纵向神经认知轨迹之间的关联.
- 检查与艾滋病毒感染者 CD4 数量最低值相关的特定领域的神经认知变化.
主要方法:
- 在132名HIV+成年人中进行了长度神经认知评估.
- 线性混合模型分析了CD4极点对速度/执行功能,视觉空间记忆和口语流性的影响.
- 随着时间的推移,CD4动态被探索为潜在的调解因素.
主要成果:
- CD4 nadir与言语流性 (p=0.020) 的变化有显著关联,但不是速度/执行功能或视觉空间记忆.
- 具有CD4极点<200细胞/毫升的个体随着时间的推移表现出语言流性得到改善 (p=0.002),而CD4极点>200细胞/毫升的个体表现出稳定的语言流性 (p=0.568).
- 随着时间的推移,CD4的动态产生了关于它们作为机制的作用的混合发现.
结论:
- 低CD4值与10年后艾滋病毒感染者持续的神经认知能力下降无关.
- 与纳迪尔相关的口语流性缺陷可能会稳定或改善,可能是由于长期治疗和免疫复原.
- 这些发现挑战了仅仅基于CD4数量最低点的持续性,渐进性神经认知障碍的概念.
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