成年妇女患有垂体茎中断综合征的淋巴腺状况
Aglaé Terray1,2, Bertrand Baussart3,4, Marie Zins5
1Department of Endocrinology, Diabetology and Nutrition, Ambroise Paré University Hospital, Assistance Publique-Hôpitaux de Paris, F-92100 Boulogne Billancourt, France.
European journal of endocrinology
|June 10, 2024
概括
患有垂体茎中断综合征 (PSIS) 的女性往往缺乏自发性青春期,并面临降低生育能力. 早期关于淋巴体功能下降的信息对于管理这些患者的生殖健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
背景情况:
- 垂体茎中断综合征 (PSIS) 是一种罕见的先天性疾病,导致垂体下垂体.
- 对于患有PSIS的成年女性的长期生殖结果,数据有限.
研究的目的:
- 描述患有PSIS的成年女性的青春期发展.
- 评估患有PSIS的成年女性性腺功能和生育能力的演变.
- 将生育率和代谢参数与年龄匹配的对照进行比较.
主要方法:
- 法国的一项回顾性多中心研究,涉及56名患有PSIS的成年女性.
- 从青春期开始评估性腺功能.
- 与CONSTANCES队列的活产率,人体测量,代谢和社会经济数据的比较.
主要成果:
- 在56名女性中,36名女性没有达到自发性青春期;在卵巢刺激后,7名妇女生育了孩子.
- 20名处于自发性青春期的女性经历了8次怀孕,但6名患有二次性腺激素缺乏症.
- 与对照组相比,患有PSIS的女性生育率 (0.33比0.63) 和身高明显较低.
结论:
- 患有PSIS的女性的生育预后需要改进和优化.
- 随着时间的推移,淋巴腺功能下降是常见的,患者应该被告知.
- 虽然代谢参数相似,但患有PSIS的女性关系较少.
相关概念视频
Hormonal Control of the Ovarian Cycle
468
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
468
Menopause
155
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
155
Hormones of the Pituitary Gland
6.5K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
6.5K
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Hormonal Regulation of the Menstrual Cycle
342
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
342
Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K


