相关实验视频
Updated: Jun 24, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.2K
体积和发生事故的风险 结局
Jianhan Wu1,2, Yifan Wang2, Caitlyn Vlasschaert3
1Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Journal of the American Society of Nephrology : JASN
|June 10, 2024
概括
低体积 (TKV) 与患慢性病 (CKD) 的风险更高有关. 这项研究证实体积是CKD的独立预测因素,揭示了体积和疾病进展之间的双向关系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
- 遗传学 遗传学 是一个
背景情况:
- 低体积 (TKV) 是慢性病 (CKD) 的已知危险因素.
- 现有的研究缺乏对TKV超出已知生物标志物的非线性关联,事件事件,因果推理和预后效用的全面分析.
研究的目的:
- 研究TKV与发生慢性病 (CKD),急性损伤 (AKI) 和心血管事件之间的关联.
- 评估TKV在CKD风险分层中的预后效用.
- 使用孟德尔随机化,探索基因预测的TKV与脏/心血管特征之间的双向关系.
主要方法:
- 从34,595名英国生物银行参与者获得了TKV,高度调整的TKV和BSA-TKV.
- 采用Cox的比例危险模型来评估与发生的CKD,AKI和心血管事件的关联.
- 利用孟德尔的随机化来检查TKV与脏/心血管特征之间的因果关系.
主要成果:
- 较低的TKV (10毫升) 与6%的发生性CKD风险增加相关,独立于eGFR和白蛋白尿.
- TKV没有显示与事件AKI或心血管事件的关联.
- BSA-TKV和预后值提高了CKD风险预测的准确性.
- 门德尔的随机化揭示了基因预测TKV和CKD风险之间的双向联系.
结论:
- 体积是发生CKD的独立预测因素,超出了传统的风险因素.
- 体积和CKD之间存在双向因果关系.
- 在CKD风险分层方面,TKV具有预后价值.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
84
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
84
01:12Internal Anatomy of the Kidney
1.6K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.6K
01:45Kidney Structure
69.5K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
69.5K
01:11Renal Failure: Dose Adjustments
84
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
84
01:10Nephrons
2.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125