间歇性缺氧训练对依赖氧的过程的适应性影响,作为潜在的治疗策略工具
Natalia Kurhaluk1, Oleksandr Lukash2, Piotr Kamiński3,4
1Institute of Biology, Pomeranian University in Słupsk, Arciszewski Str. 22b, 76-200 Słupsk, Poland, natalia.kurhaluk@upsl.edu.pl.
概括
间歇性缺氧训练 (IHT) 通过增加氧化的产生来提高适应潜力. 这种训练,特别是L-氨酸的训练,促进了对老鼠氧化应激的长期保护作用.
科学领域:
- 生理学 生理学 生理学
- 生物化学 生物化学
- 运动科学 运动科学
背景情况:
- 间歇性缺氧训练 (IHT) 是提高适应潜力的有效方法,特别是在涉及急性缺氧的病态状态中.
- 氧化 (NO) 系统在调解对缺氧的适应性反应方面发挥着至关重要的作用.
- 了解IHT,NO系统和氧化应激之间的相互作用对于治疗应用至关重要.
研究的目的:
- 评估氧化系统 (亚酸盐,亚酸盐,胺,多胺) 响应IHT的机制.
- 评估IHT对ADP刺激的氧气消耗和心脏和肝脏线粒体中的氧化酸化的影响.
- 研究IHT对血液,心脏和肝脏中的氧化应激生物标志物的影响,与或没有L-氨酸或L-NNA治疗的老鼠.
主要方法:
- 鼠被暴露于IHT和急性缺氧,并先接受L-氨酸或L-NNA的治疗.
- 使用氧图和生物化学方法分析了线粒体呼吸,微体氧化和脂氧化.
- 评估了短期和长期影响 (30,60,180天IHT后),重点关注线粒体功能和细胞适应.
主要成果:
- IHT显著增加了内源性氧化的产生,酸盐离子水平在血和红细胞中上升了近7倍.
- 在IHT之前的L-氨酸给药持续增加了NO循环中酸盐降解成分的水平,长达180天.
- IHT调节了能源供应中的代谢转化,可能降低了血和肝脏中的尿素和聚胺产量.
结论:
- IHT的有效性与其依赖酸盐的成分有关,促进长期的适应性反应.
- 通过改变抗氧化剂防御酶和稳定红细胞膜,IHT可以预防增加的脂质过氧化.
- 这些适应对依赖氧气的过程的整体调节产生保护作用.
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