素补充剂加快了抗生素后肠道微生物组的复合,并减少了肠道氧化还原潜力
Rongying Xu1,2, Ni Feng1,2, Qiuke Li1,2
1Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
The ISME journal
|June 10, 2024
概括
素补充剂有助于在抗生素诱导的失生症后肠道微生物的恢复. 它减少了肠道氧化还原潜力,促进了有益的无氧细菌,加速了宿主健康的恢复.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 抗生素诱导的肠道失调 (AID) 损害了宿主健康,其特点是氧化还原潜力和有氧代谢的增加.
- 从AID中恢复往往是缓慢和不完整的,这给健康带来了重大挑战.
- 之前的研究表明,点能够降低便的氧化还原潜力,并调节肠道微生物群.
研究的目的:
- 在大鼠中研究丁补充剂在促进肠道微生物组在AID后复合的疗效.
- 为了确定点氨酸是否可以调节肠道氧化还原潜力,并有利于从失生症中恢复.
- 探索素调节的便微生物群移植在恢复肠道平衡中的作用.
主要方法:
- 利用一种抗生素诱导的肠道失生症的老鼠模型.
- 服用素补充剂和素调节的便微生物群移植.
- 测量了肠道氧化还原潜力,肠道细菌群负载,以及肠道微生物组的组成和功能.
- 分析了微生物新陈代谢的变化,重点关注合成代谢的降解和合成代谢的氧化途径.
主要成果:
- 素补充剂显著加快了肠道微生物组合和功能后抗生素复合的速度.
- 氨酸增强了合成代谢的降解代谢和减少了合成代谢的氧化途径,由减少的氧化还原潜力证实.
- 素调节的便微生物群移植模仿了这些效应,降低了氧化还原潜力和Enterobacteriaceae负载.
- 这两种干预措施都丰富了厌氧细菌,特别是Lachnospiraceae,并增强了微生物的还原代谢.
结论:
- 素补充剂通过减少肠道氧化还原潜力,有效地加速了抗生素后肠道微生物群的恢复.
- pectin对氧化还原潜力的有益作用是通过肠道微生物群的重塑来实现的.
- 素代表了一种有希望的饮食策略,可以缓解AID并促进肠道健康的恢复.
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